Restart USB Mouse Driver after Mouse Freeze

VirtualBox 5.1.18 
Centos 7.3 

Switching to  text mode with              
   Ctrl+Alt+F7 
and immediately returning  to graphical mode with 
   Ctrl+Alt+F1 
may fix the problem

Reference

https://unix.stackexchange.com/questions/49272/restart-usb-mouse-driver

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